Supporting the Newborn Gut Microbiome

Oligosaccharides, a major component of mare’s milk, are indigestible by the nursing foal

  • Naturally occurring complex carbohydrates in the mare’s milk cannot be digested by the foal
  • These compounds are specifically utilized by bacteria in the foal's large intestine
  • The colonization of specific beneficial bacteria supports intestinal health during the vulnerable first weeks of life

The diverse set of oligosaccharides in mare’s milk are preferentially consumed by Bifidobacterium

  • UC Davis and Evolve have pioneered the characterization of oligosaccharides in mare’s milk, from colostrum through early lactation
  • Several novel structures were discovered, and mare’s milk was found to contain high concentrations of sialylated and N-acetylated oligosaccharides
  • These diverse carbohydrates are consumed by Bifidobacterium and Lactobacillus, and converted to short-chain fatty acids

Sela et al. Journal of Biological Chemistry 2011
Marco et al. Environmental Microbiology 2009

GlycoGuard™, an activated form of B. infantis and L . plantarum, remodels the foal gut microbiome

  • Newborn foals were administered GlycoGuard immediately after birth, and twice daily for the first two days of life
  • Absolute abundance of fecal B. infantis was significantly increased immediately following supplementation with GlycoGuard, and remained elevated over the 14-day sampling period
  • The is the first time persistent colonization of a probiotic has been demonstrated in foals (Schoster et al. JVIM 2014)
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